Sublingual B12 reduces Homocysteine
Nature's Steps to Alzheimer's Treatment
More than likely, you’ve never heard of homocysteine. Although it was first described in the 1930s and its instrumental role in causing heart disease was discovered in the late 1960s, homocysteine has gone relatively unnoticed and underappreciated by the medical community—until recently. Homocysteine is an amino acid that occurs naturally in your body as it processes protein. When you ingest the essential amino acid, methionine, it must be broken down into non-essential amino acids. An essential amino acid is a protein you must have to live. A non-essential amino acid may be made from essential proteins. A very important protein, methionine, is used to make many other important proteins.
Homocysteine is used in many of the important steps your body uses to break down methionine into non-essential proteins. At the end of the cycle, homocysteine is used to recombine the “leftovers” from this process back into a little methionine. This entire process takes a lot of energy. Your body gets this energy from vitamins and other nutrients. If you don’t have enough nutrition, especially if you are B-12 deficient—either because you are not getting B vitamins from the foods you eat or because your body is not able to adequately absorb them (which happens as we age)—the methionine is not recombined and homocysteine escapes into your bloodstream. If it does, the homocysteine will eventually become toxic and will damage your arteries and brain cells.
The outcome of this toxicity is two-fold:
- Endothelial cell injury—infarctions
Stroke and/or heart attack- Neuronal injury—degenerative diseases
Alzheimer’s disease and vascular dementia
Many studies have been done on the relationship between
homocysteine levels and dementia, and while research does not conclusively
prove the relationship, it strongly suggests that homocysteine
directly promotes the development of dementia and Alzheimer’s disease.
“Plasma Homocysteine as a Risk Factor for
Dementia and Alzheimer’s Disease” Published in The New England
Journal of Medicine, Vol. 346, No.7 Sudha Seshadri, M.D, et. al.
| One study showed that patients with clinically diagnosed dementia of
Alzheimer type had significantly higher homocysteine levels
than control subjects. Folate and vitamin B-12 levels were
significantly lower in Alzheimer’s patients than in controls.
| An increase in the plasma homocysteine level of 5 µmol per liter
increased the risk of Alzheimer’s disease by 40%.
| A plasma homocysteine level greater than 14 µmol per liter doubled the
risk of Alzheimer’s disease. | |
Researchers also found that when plasma B-12 concentrations
increased and homocysteine concentrations decreased, electrographic tests
showed signs of improved cerebral function and improved cognitive function. Patients
saw improved memory functions, less disorientation, and improved attention and
processing speed after vitamin supplementation.
“Improvement of cognitive functions
after cobalamin/folate supplementation in elderly patients with dementia and
elevated plasma homocysteine.”
Published in the International Journal of Geriatric Psychiatry Karin
Nilsson, et. al.
http://www.sublingualb12.com/B-12_Benefits/alzheimer_prevention.htm?GTSE=goto>KW=
The miracle is vitamin B-12, a common vitamin found in everyday foods and multivitamins that you may already be taking. B-12 is extremely vital in brain and nerve function—playing an integral part in memory. However, according to medical science, as you age, your body's ability to absorb vitamin B-12 through food and pills decreases. In fact, many adults may be unable to absorb vitamin B at all and have to receive expensive B-12 shots each month!
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The word “sublingual” literally means “under the tongue.” It refers to a method of administering substances in the mouth so that they can be rapidly absorbed into the blood vessels. The substance is absorbed through the buccal mucosa and into the sublingual vein where it has direct access to the blood circulation and is then carried throughout the whole body. Medical science has been using this method for years in the administration of cardiovascular drugs, steroids, and some barbiturates. The sublingual method has been life-saving for individuals who have had to rely on its speed and efficiency during times of critical emergency.
When the B-12 vitamin enters your body in the stomach (through food or oral pills), acids in the stomach separate the B-12 from its protein source. It then must combine with intrinsic factor cells in the stomach. This B-12/intrinsic factor complex travels to your intestine, where it is absorbed in the terminal ileum. The absorbed complex is then transported via blood plasma and stored in the liver.
The interruption of any of these steps affects your body’s ability to absorb B-12. Here is a list of common interruptions to B-12 absorption:
 | Gastrectomy eliminates the site of intrinsic factor production.
| Blind loop syndrome results in competition for vitamin B-12 by
bacterial overgrowth in the lumen of the small intestine.
| Surgical resection of the ileum eliminates the site of vitamin B-12
absorption. | |